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The pharmacological and sub-pharmacological doses of pioglitazone were 2.0 mg/kg and 0.2 mg/kg body weight in the WPK / model, and for rosiglitazone, it was 0.4 mg/kg and 0.04 mg/kg body weight in the PCK model

2 mg: 4.6% (P = 0.002) SAFETY & TOLERABILITY GI AEs significantly at 8 & 16 mg ~30% dropout in high-dose arms Dysesthesia (18% in 16 mg group) reportedfirst time seen with s.c

This is why some maternal-fetal medicine specialists may recommend continuing GLP-1 therapy through early pregnancy in high-risk cases, though this remains a shared decision-making conversation with your clinical team, not a standard protocol

References Accessed 6th of June, 2025

REFERENCES 1.Walters JR