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The structural similarity between ERR and estrogen receptor DNA-binding domains raises theoretical questions about potential crosstalk, though SLU-PP-332 has been shown to be selective for ERRs over ERs in biochemical assays

But It comes with significantly higher discontinuation rates A concerning rate of dysesthesia And potential cardiac safety issues that require further investigation The headline 28.7% weight loss is impressive but the real-world difference vs tirzepatide is only about 3% , and side effects may be more pronounced

Alongside this, mild nausea, bloating, and indigestion are common as the body adjusts to slower gastric emptying

Notably: HbA1c improvement did not mediate cancer risk reduction Data are from first-generation GLP-1snewer agents like tirzepatide werent included Long-term adherence and treatment durability still need clarification Bottom line: GLP-1s may be approaching BMS in long-term cancer prevention for people with diabetes and obesity

Healthcare workers on rotating shifts, for example, might find evening dosing more consistent than morning administration