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Description
Introduction and Importance Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is increasingly used for glycemic control, weight loss, and cardiovascular risk reduction
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Although people with obesity display higher energy expenditures than their lean counterparts, these decrease substantially in the setting of weight loss

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A promising insulin analog, TBE001-A-S033, was synthesized and conjugated, and its efficacy was assessed in ICR and db/db mice