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Pharmacological inhibition or genetic reduction of DPP-4 activity preserves much higher circulating levels of intact GLP-1 [191,192], and this was demonstrated to potentiate the insulinotropic effect of GLP-1 in anesthetized pigs (eventually leading to the development of DPP-4 inhibitors for clinical use) [193]

[8] Metformin with GLP-RA & Long-term Outcomes: In patients with T2D, dual therapy with metformin and GLP-RA has demonstrated a 39% lower incidence of adiposity-related cancers (HR 0.61) and a 67% reduction in all-cause mortality (HR 0.33) compared to DPP-4 inhibitor use, with effects most pronounced in younger people with obesity

GLP-1 medications work by binding to the GLP-1 receptors throughout your body, triggering a cascade of beneficial effects

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