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for direct oral anticoagulants, reduced renal perfusion from weight loss can alter drug exposure

These effects are usually dose-dependent and resolve with dose reduction

Ongoing pharmacovigilance remains essential as these medications are used in increasingly diverse populations and for longer durations

Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats

Finally, for patients on anabolic medications, awareness of the symptoms of hypercalcemia (nausea, fatigue, bone pain, confusion, increased thirst and urination) is worth having, as this is a known risk of parathyroid hormone analogs