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There is a legitimate clinical argument that a healthy 35-year-old with a BMI of 33, no comorbidities, no relevant family history, and no medications can safely start a low-dose GLP-1 agonist without requiring a full metabolic workup first particularly if the prescriber is using a thorough intake questionnaire to screen for contraindications

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Studies have reported that excessive intake of histidine can cause hepatic steatosis ( The pro-inflammatory cytokines (IL-6 and TNF-) released during the pathophysiology of NAFLD are mainly derived from macrophages ( Arachidonic acid, a polyunsaturated fatty acid metabolized by cyclooxygenase and lipoxygenase pathways, can mediate inflammation and participate in the development of NAFLD