semaglutide and creatine + Semaglutide: Safety & Muscle Loss Prevention – PlexusDx Creatine and GLP-1 Medications: Safety

Choose vitamin D3 (cholecalciferol) over D2, and combine it with a small amount of dietary fat for absorption

Ozempic can be dispensed at Clicks, Dis-Chem, Medirite, or delivered through a telehealth provider Nausea, vomiting, diarrhoea, stomach pain, and constipation are the most common side effects Acute pancreatitis and severe allergic reactions are rare but serious risks

A commercial branded auto-injector pen is expected at FDA approval, but no device specification has been officially released by Lilly as of May 2026

The bottom line There are lots of positive health benefits from using a GLP-1 to eat less and lose weight, but there are also a few challenges, especially losing bone density and muscle mass

Considerations Limited Research: Theres minimal research on combination therapy with GLP-1 and GLP-2