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142 GLP-1 receptors in the mesolimbic system are implicated in the modulation of reward behavior, 143 whereas brain imaging studies document GLP-1-induced changes in brain regions related to appetite and reward, such as the insula, amygdala, putamen, and orbitofrontal cortex

It has therefore been considered suboptimal when evaluating treatment effects in clinical trials [71, 72]

Proper injection technique, including rotation of injection sites and allowing the medication to reach room temperature before administration, may help minimize these local reactions

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Patients should expect subtle rather than dramatic changes