what are the long-term effects of glp-1 long term glp 1 use Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients GLP-1 drugs can cause pancreatitis,

doi: 10.1038/s41586-024-07469-y

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

PIONEER 5 The PIONEER 5 study enrolled patients with T2DM and moderate renal impairment (estimated glomerular filtration rate [eGFR] of 3059 mL/ min/1.73 m 2 ) to examine the efficacy and safety of oral semaglutide in patients with compromised kidney function

Therefore, these drugs should not be given to people with uncontrolled T2D, polyuria, and polydipsia or people who develop severe symptoms that predispose to volume depletion (for example vomiting)

GLP-1 drugs do not carry seizure risk or cause stimulant-like side effects