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These results suggest that GLP-1RAs regulate SREBP-2 and its downstream targets through increased AMPK and SIRT6 expression in PA-treated HepG2 cells, and that SIRT6 may partially function as an upstream regulator of AMPK

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The patients who underwent liraglutide treatment showed significant improvement in body weight, body mass index, and HbA1c and -glutamyl transferase (GGT) concentrations compared to the placebo, whereas no difference was observed in the change in serum aminotransferase concentrations

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Common side effects of semaglutide include: Digestive symptoms such as nausea, constipation, or diarrhea often improve within a couple of weeks after the last dose
