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Gallbladder Effects Even small doses of curcumin (20-80 mg) can stimulate gallbladder contractions and could increase pain during stone passage or potentially increase perforation risk in people with gallstones [121]

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The STEP (Semaglutide Treatment Effect in People with obesity) trials, which included over 4,500 participants, showed that semaglutide 2.4 mg weekly resulted in mean weight loss of 12.4% to 15.3% of initial body weight over 68 weeks, compared to 2.4% to 3.2% with placebo

Lindicazione terapeutica da parte dellEMA (European Medicines Agency) comprende gli adulti con BMI 30 kg/m (obesit) o con BMI 27 kg/m (sovrappeso) in presenza di comorbidit associate al peso corporeo, quali ipertensione arteriosa, dislipidemia o diabete di tipo 2