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GLP-1s also reduce your appetite, so you end up eating less

Beyond potential direct receptor-mediated effects, it is more plausible that GLP-1RAs influence thyroid physiology indirectly by modulating systemic inflammation, adipokine signaling, and immune tolerance, thereby affecting the autoimmune milieu rather than acting on thyroid tissue itself [9]

2 New classes of medications, such as the dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium-glucose cotransporter- 2 (SGLT-2) inhibitors, specifically target some of the more recently identified defects described in the ominous octet to help manage uncontrolled hyperglycemia

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