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Description
The appetite suppression effect is the most noticeable for weight loss

In the same clinical trial, the incidence of constipation was 7% with 1 mg, 6-15% with 4 mg, 6-11% with 8 mg, and 16% with 12 mg dose of retatrutide compared to 3% in the placebo group

Maybe the appetite suppression that everyone raves about never kicked in for you

Doses become larger than intended, increasing the risk of side effects and accelerating through your dose escalation faster than planned
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This is more relevant for managing side effects than for weight loss optimization