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Notably, elevated plasma biomarker concentrations are linked to reduced white matter quality (Figure 3A and B), showing brain regions where GFAP and, to a smaller extent, NfL concentrations are amplified, affecting neurite density reduction and neuronal health processes

Preliminary evaluation does not suggest a causal link [20]

(2023) study examined the impact of GLP-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) on lower limb amputation (LLA) risk using Danish National Health Service registry data from 2013 to 2018

Sleep and Neuropsychiatric Effects SSRIs exert heterogeneous sleep effects, with fluoxetine and sertraline generally activating sleep, while paroxetine remains sedating and is sometimes leveraged in patients with comorbid insomnia [21,57]

Acute pancreatitis is an uncommon but recognised adverse effect of GLP-1 medications