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[DOI] [PMC free article] [PubMed] [Google Scholar] 263.Cottone P., Sabino V., Roberto M., Bajo M., Pockros L., Frihauf J.B., Fekete E.M., Steardo L., Rice K.C., Grigoriadis D.E., et al

Dapagliflozin and sitagliptin forms an essential part of the current armamentarium for appropriate cardiometabolic risk management in T2DM which seem to be safer, shown to achieve rapid and sustained glycemic control especially associated with improvement in both insulin resistance and beta cell function.

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This process is accompanied by the activation of protein kinase C (PKC) and the production of intracellular Ca 2+ influx through IP3 receptors