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If the FDA will require outcomes trials for future approvals in obesity, this will add considerable time and cost to drug development

Historically, natural products have demonstrated considerable potential as a source of drug discovery with the help of their chemical structure and recent endeavors on this field have focused on investigating the GLP-1 activating capabilities of various products which are naturally sourced from traditionally employed medicinal flora or nutritional origins

Retatrutide is not commercially available

Similarly, semaglutide GLP-1 costs are estimated between $900 and $1,800 monthly

These agents are FDA-approved primarily for the management of type 2 diabetes mellitus and, for specific products (Wegovy, Saxenda, Zepbound), for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity