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Acknowledgements Medical writing and editorial assistance was provided by Andy Bond and Emma Marshman of Spirit Medical Communications Ltd, and was supported by Novo Nordisk A/S

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The 46 mm pen needle is short enough that it cannot reach a blood vessel in subcutaneous tissue, and current guidelines specifically advise against aspiration

Further research is needed to more clearly elucidate both if GLP-1-mediated glucose uptake in hepatic tissue is exclusively through extrahepatic GLP-1R activation and if GLP-1R is distributed in human hepatic tissue

TAM cell type: F (2,42) = 6.501, p = 0.0035