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A 2022 analysis published in Diabetes, Obesity and Metabolism found that semaglutide treatment was associated with significant improvements in patient-reported energy levels and physical functioning scores, with improvements correlating with both weight loss magnitude and reductions in inflammatory markers (Wilding et al., Diabetes, Obesity and Metabolism, 2022, What GLP-1 Medications Cannot Do for Fatigue This is worth addressing directly, because theres a real risk of patients attributing all their fatigue to weight and expecting GLP-1 medications to fix everything

For her part, Cayman would like physicians to learn more about how to avoid inadvertent fat-shaming

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