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These benefits likely arise through a combination of weight-mediated and weight-independent mechanisms, including natriuresis, improved vascular function, and autonomic modulation

Patients should be educated about DKA symptoms (nausea, vomiting, abdominal pain, excessive thirst, frequent urination, fatigue, fruity-scented breath) and when to seek urgent care

Similarly, other animal experiments have noted reductions in testicular inflammatory cytokines and improved sperm parameters with GLP-1 RA therapy, hinting at direct beneficial effects on the testis microenvironment

Some patients who need continuous treatments may prefer oral products since they minimize needle phobia, hassle associated with injections, storage difficulties, and injection fatigue that comes with GLP-1 injectables

doi: 10.3390/ph18030399