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The Discovery Of Oral Semaglutide The short half-life of human GLP-1 resulting from degradation by DPP-4 has raised a challenge for pharmaceutical use in the clinical setting where a constantly high and stable plasma level is required

[DOI] [PMC free article] [PubMed] [Google Scholar] 1831.Remschmidt C, Wichmann O, Harder T

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This is a previously unknown form of mitochondrial-to-nuclear retrograde signaling