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Cigna will stop covering GLP-1 weight-loss drugs such as Wegovy and Zepbound for its employees starting July 1, signaling that even major healthcare companies are struggling with the high cost of these medications

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However, some patients do report irritability, which is most often related to indirect factors such as under-eating, blood sugar fluctuations, sleep disruption, or changes in reward signaling rather than the medication itself.This post explains the science behind these effects, identifies who may be more vulnerable, and outlines practical strategies clinicians and patients can use to reduce risk