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An avenue for future work is to assess thyroid cancer risk by individual GLP1 receptor agonist

The HPA axis involves a neuroendocrine cascade, initiated by corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) neurons of the hypothalamic paraventricular nucleus (PVN), which stimulate pituitary adrenocorticotrophic hormone (ACTH) release and subsequent adrenocortical synthesis and secretion of glucocorticoids

The EMA's Pharmacovigilance Risk Assessment Committee (PRAC) has reviewed this issue and found no proven causal link with suicidal ideation, though monitoring continues

[4] For weight management, clinically meaningful weight loss is generally defined as 5% or more of initial body weight

Notably, in one of the few studies in which obesity was associated with suicide completion, the most substantial risk factor was a sudden and unexplained loss of weight [184]