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Description
3 GADPH = Glyceraldehyde- 3-phosphate dehydrogenase, 4 MMP-1/3/13 = matrix metalloproteinase 3/13
Dual receptor agonists can activate both GIP and GLP-1 receptors
When present alongside other cardiovascular risk factors, obesity and type 2 diabetes compound the risk of myocardial infarction, stroke and premature death, escalating both individual and public health burden 5,6
Several GLP-1 receptor agonists have demonstrated cardiovascular benefits in outcome trials
Some GLP-1 agonists (particularly semaglutide) carry warnings about diabetic retinopathy complications
