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Description
Incretin-based therapies currently represent one of the cornerstones in the management of type 2 diabetes mellitus and obesity, owing to their ability to integratively modulate cardiometabolic risk

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Then, the proprotein convertase Furin recognizes and cleaves a specific sequence in Pro-GDF-8 to form Latent GDF-8, a key step in GDF-8 maturation
