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GLP-1 medications bind to and activate the GLP-1 receptor in the brain, pancreas, gut, heart, liver, kidneys and blood vessels, triggering a wide range of beneficial metabolic effects. Meanwhile, tirzepatide is a dual GIP/GLP-1 receptor agonist that targets both GIP and GLP-1 receptors

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Some patients remain at 8mg if side effects at 12mg prove uncomfortable

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