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The timeframe of improvementwith some patients reporting skin changes before reaching their lowest weighthints that GLP-1 signaling may provide independent anti-inflammatory benefits beyond weight reduction alone

It reduces how many calories go in while increasing how many calories go out

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TGR5 and Its Physiologic Effects Relevant to GLP-1 and Glycogen Metabolism Takeda G protein-coupled receptor 5 (TGR5), a G protein-coupled bile acid receptor, contributes to improved hepatic insulin sensitivity and subsequent energy metabolism and homeostasis [139]
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On the contrary, the genera (such as Bifidobacterium) belonging to the phylum Bacillota were negatively associated with these metabolic parameters, and they were all increased in the PCOS+Liraglutide group
