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Table 2 presents the data, findings, and conclusions of these meta-analyses

2012 Jan;38(1):104-10

15 This divergence between small molecule (5 years) and biologic (12 years) exclusivity has created a strategic incentive for pharmaceutical companies to prioritize biological development, particularly in light of new pricing negotiation frameworks that treat the two modalities differently

However, the labeled dose paths differ by product and indication

Favourable changes in cardiometabolic markers were also reported in the Phase 2 trial data, including reductions in: Systolic blood pressure Triglyceride levels Waist circumference (a proxy for visceral adiposity) However, these are surrogate markers and should not be interpreted as evidence of a reduction in major adverse cardiovascular events (MACE)