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Description
Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use these medications
The incretin effect is exclusively glucose-dependent and critical for the maintenance of glucose homeostasis

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Label updates in 2023 through 2025 added disclosures for ileus, intestinal obstruction, and other complications

In addition to its extensively studied actions in peripheral tissues, studies have evaluated the distribution of GLP-1R in the central nervous system (CNS) of rodents, non-human primates, and humans, showing that it is widely diffused to multiple CNS neurons including neurons of the arcuate nucleus (ARC), which are crucial for the control of energy balance (Fig
