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[DOI] [PubMed] [Google Scholar] 32.Kotronen A., Peltonen M., Hakkarainen A., Sevastianova K., Bergholm R., Johansson L.M., Lundbom N., Rissanen A., Ridderstrle M., Groop L., et al

GI symptoms you may experience when starting a GLP-1 drug include: One 2024 review of several studies found that people receiving semaglutide injections had a significantly increased risk of certain GI symptoms compared to those who didnt use a GLP-1 drug

We have previously found that cell GLP-1RKO leads to an increased number of islets containing centrally located cells, suggesting that the cell GLP-1R regulates normal islet morphology (24)

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Orlistat, a lipase inhibitor that reduces fat absorption, represents an alternative pharmacological option with a different mechanism of action, though it also carries gastrointestinal side effects including oily or fatty stools