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"Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice" Aging (Albany NY) 13(18):21962-21974

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These differences may inform medical management and device interventions for HFimpEF patients
Conclusions Collectively, these data demonstrate that blockade of ActRII signaling improves body composition and metabolic parameters during calorie deficit driven by GLP-1 receptor agonism and demonstrate the existence of Akt-independent pathways supporting muscle hypertrophy in the absence of ActRII signaling

The number of studies examining newer medicines like semaglutide and tirzepatide remains relatively small, and follow-up durations after stopping medicines were generally short, meaning some estimates are modelled projections beyond observed follow-up
