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"Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice" Aging (Albany NY) 13(18):21962-21974

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These differences may inform medical management and device interventions for HFimpEF patients

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Conclusions Collectively, these data demonstrate that blockade of ActRII signaling improves body composition and metabolic parameters during calorie deficit driven by GLP-1 receptor agonism and demonstrate the existence of Akt-independent pathways supporting muscle hypertrophy in the absence of ActRII signaling

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The number of studies examining newer medicines like semaglutide and tirzepatide remains relatively small, and follow-up durations after stopping medicines were generally short, meaning some estimates are modelled projections beyond observed follow-up

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