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It may also improve bone density, lowering the risk of osteoporosis in older adults

Role of leptin in the regulation of glucagonlike peptide1 secretion

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In ATTAIN-1, adverse event-related discontinuation rates were 5.3% with orforglipron 6 mg, 7.6% with 12 mg, and 10.3% with 36 mg, compared with 2.7% with placebo