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TRIUMPH-1 Phase 3 topline results, 21 May 2026

This dehydration risk is the primary concern prompting temporary metformin discontinuation

BI 456906 (survodutide), developed as a dual agonist for GLP-1 and glucagon receptors for the treatment of obesity and NASH, is structurally modified from glucagon [109]

A comparative study conducted between GLP-1RA + Metformin in contrast to cyproterone acetate/ethinylestradiol + Metformin in overweight PCOS women, conducted over a period of 12 weeks, implied that GLP-1 RA+Metformin was superior in reducing the waist circumferences as well as preserving blood sugar levels by improved HbA1c levels and regulating menstrual cycle

Important side effects that warrant immediate attention by a doctor include persistent vomiting, diarrhea and/or abdominal pain