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We also performed time to event analysis using Cox proportional-hazards regression model to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for all-cause mortality and cardiovascular composite event outcome for GLP1-RA group compared to DDP4i group

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By inhibiting the reuptake of monoamines, such as dopamine, norepinephrine, and serotonin in the central nervous system, Sibutramine increases their concentration [106, 126,127,128]

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82 The emerging interplay between GLP-1R signaling and the gut microbiota raises the possibility that this pathway may influence microbial composition and hostmicrobe interactions relevant to IBD