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Importantly, analysis of biomarkers in exosomes showed a clear insulin desensitization in the brains of patients who took part in this trial
Nature 500:541546
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Understanding the implications of upstream GLP-1 signaling may provide context for metabolic disease states, where abnormalities in the TGR5 signaling pathway attenuate robust GLP-1 activity
That is over a decade of real-world safety data across millions of patients
