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Achieving nearly 30% weight loss with a medication challenges previous assumptions about the upper limits of drug-induced weight reduction and brings us closer to the efficacy seen with bariatric surgery (30-40% weight loss), but without the surgical risks and recovery time

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Liraglutide is a long-acting GLP-1RA that is more prone to tachyphylaxis related to delayed gastric emptying than short-acting GLP-1RAs such as exenatide 38

Additionally, these medications may influence stress and anxiety pathways
