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Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down

Group, HARMONY 3: 104-week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin, Diabetes care, 37 (2014) 21412148

The Road Ahead: Oral Dominance Is Not Inevitable Despite the growing commercial momentum surrounding oral GLP-1 therapies, the segment continues to face several important challenges that may affect long-term adoption and market expansion

5 Inflammation and oxidative stress It has been widely accepted that chronic low-grade inflammation is involved in the pathogenesis of PCOS, mainly owing to the excessive fat accumulation observed, particularly in the visceral adipose tissues (36, 37)

GLP-1 medications cause nausea primarily because they slow gastric emptying, meaning food stays in the stomach longer