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The SURPASS trials, which studied tirzepatide in type 2 diabetes populations, showed similar patterns
Main finding: people taking retatrutide lost substantially more weight than people taking placebo

Despite the elevated heart rate, cardiovascular outcome trials have shown net cardiovascular benefits, suggesting that the modest chronotropic effect is outweighed by other protective mechanisms
However, it is important to note that, due to potential underreporting by the informants, there were also instances of unknown indications ( n = 2,281, 27.68%)
