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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]

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Normally, that stretching comes from the arrival of food, Shriya Srinivasan explains

However, at pharmacological concentrations achieved with therapeutic GLP-1 receptor agonists (100 pM10 nM), -arrestin-2 becomes essential for sustained signaling, specifically mediating extracellular signal-regulated kinase (ERK) activation and CREB phosphorylation that promotes pancreatic -cell survival and insulin synthesis