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doi: 10.1038/npp.2014.74 32 AlhadeffALRupprechtLEHayesMR

Higher, weight-loss-level doses report more

Large cardiovascular outcome trials (e.g., Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER), SUSTAIN) and post-marketing surveillance have not demonstrated an increased incidence of MTC in humans, though long-term pharmacovigilance continues given the rarity of this malignancy [30,62]

Bone Density Deserves Attention Rapid weight loss at any age can reduce bone mineral density, and this risk is amplified after 50 when bone density is already declining, particularly in postmenopausal women

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