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Effect on Obesity and Diabetes Obesity, particularly central obesity, is a major contributor to metabolic syndrome, which includes insulin resistance, type 2 diabetes, dyslipidemia, and hypertension

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The most common causes are gallstones and heavy alcohol use

[DOI] [PubMed] [Google Scholar] 94.Alkhouri N, Herring R, Kabler H, Kayali Z, Hassanein T, Kohli A, Huss RS, Zhu Y, Billin AN, Damgaard LH, Buchholtz K, Kjr MS, Balendran C, Myers RP, Loomba R, Noureddin M

As different classes of drugs target different aspects of T2DM via distinct mechanisms of action, a combination of treatments is generally more effective at maintaining glycaemic control than monotherapy over the long term [12]