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34 The Systematic Multi-Domain Alzheimer Risk Reduction Trial (SMART), a RCT with a 2-year personalized, risk-reduction intervention with health coaching and nurse visits in 172 older adults at risk for dementia, led to modest improvements in cognition

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Immunohistochemical analysis revealed decreased c-Fos activation in the central amygdala and increased GLP-1R expression in the NAc, indicating recruitment of inhibitory control over affective and motivational drug circuits
