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Other results also suggest that GLP-1 increases ER-mitochondria communication in vascular smooth muscle cells, resulting in higher mitochondrial activity 76
Yet cardiomyocytes, the main muscle cells of the heart, and hepatocytes in the liver do not appear to express GLP-1 or GIP receptors in significant amounts
What makes Retatrutide different is that instead of mimicking two hormones, it mimics three: GIP, GLP-1, and Glucagon
Because retatrutide is not yet approved by the FDA or EMA, it is not currently available through standard clinical channels
