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Description
It's important to distinguish between temporary adjustment side effects (common in weeks 14 at each dose step) and dose intolerance
Approval of GLP-1 RAs began with exenatide and liraglutide, followed by dulaglutide in 2014 and semaglutide in 2017

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Tirzepatide is actually a dual GIP/GLP-1 receptor agonist, working through two hormone pathways rather than just GLP-1

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