obesity drug glp-1 news today drugs can help you lose weight. They can't do this. A new American Heart Association statement, just published in JAMA, makes a point that doesn't get nearly enough attention in the New oral GLP-1 drug delivers
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Kapitza C, Forst T, Coester HV, Poitiers F, Ruus P, Hincelin-Mery A

This has to do with HOW weight gain occurs, and its different for each person
A study conducted on PD model mice shows that the administration of exedin-4 both prevented microglial activation in the substantia nigra pars compacta and significantly reduced the neuronal loss in that region, as well as with striatal dopaminergic nerve fibers [70]
Galic, S., Oakhill, J

This allows distinction between short term effect under up titration and more sustained impacts of GLP-1 RA, DPP-4 inhibitors or SGLT-2 inhibitors
