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Development of GLP-1GIPLani We previously showed that covalent attachment of the PPAR/ co-agonist Tesa to a pharmacokinetically optimized GLP-1R agonist enabled targeted delivery of Tesa into GLP-1R-expressing cells, leading to greater weight loss and further improvement of glucose control relative to treatment with pharmacokinetically-matched GLP-1R agonist backbone 26 (Extended Data Fig