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Amylyx updates investors on its rare disease pipeline, including avexitides Phase 3 LUCIDITY trial, AMX0035 in Wolfram syndrome, AMX0114 in ALS, and a $317M cash position with runway into 2028 through potential avexitide approval and launch in 2027.

(Madison Roberts) A Convenient New Approach to Metabolic Health Eden is providing access to a new way for individuals to explore GLP-1 therapy: a compounded semaglutide gummy, available through []

GLP-1 drugs shown cost-effective for knee osteoarthritis and obesity A new study led by investigators at Mass General Brigham finds that adding novel weight loss GLP-1 drugs semaglutide and tirzepatide to usual care represents a cost-effective treatment strategy for people with knee osteoarthritis and obesity, with tirzepatide providing greater health benefits at lower cost compared to semaglutide

Among regular drinkers, consumption plummeted from 23.2 to 7.8 units per week a 68 percent reduction, which Professor le Roux noted is comparable to that achieved by nalmefene, a drug used to treat alcohol use disorder in Europe. The potential for these weight loss drugs to reduce alcohol consumption could yield additional public health and economic benefits

This approach highlights how nutritional substrates and metabolic cofactors may influence physiological resilience during sustained pharmacological weight reduction