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Description
In addition to the hormones GIP and glucagon, other hormones such as estrogen, peptide tyrosine tyrosine (PYY), gastrin, xenin, and fibroblast growth factor 21 can be good candidates to pair with GLP-1 and create dual agonists that have anti-diabetic and anti-obesity effects
Looming even bigger is the cost issue

Exenatide is resistant to DPP-4 inactivation and has a half-life of approximately 2.4 h after s.c
Persistent pain or difficulty with swallowing

Groenewegen et al., 2020
