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Furthermore, concentrations of up to 300 mM glucose do not induce GLP-1 secretion from colonic human mucosa because GLP-1 producing L-cells barely express SGLT1 (43, 53, 58, 72)

For the multiple linear regression analysis, the variables were standardized using the scale function in R resulting in standardized beta coefficients outputs

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Additionally, many patients appreciate the positive side effects, such as weight loss, rather than severe drawbacks associated with some diabetes medications