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"Decreased libido is likely multifactorial, including caloric restriction, hormonal shifts and fatigue, and can be more pronounced in perimenopausal women," said Maccarone

Retatrutide reduces hunger through its GLP-1 component, similar to Wegovy and Mounjaro

Consumer complaints worth remembering

Probiotic supplementation is generally beneficial for GLP-1 users experiencing constipation, particularly strains like Bifidobacterium lactis BB-12 and Lactobacillus rhamnosus GG that have demonstrated improvements in transit time and stool consistency

Staying well hydrated and getting enough fibre keeps the digestive side smooth, since constipation can show up with the amylin compound