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GLP-1RA treatment enhances IL-10 secretion by M2 macrophages (133), an effect that exhibits strong concentration dependence: Low IL-10 concentrations may facilitate tumor immune evasion, whereas high concentrations promote CD8+ T cell proliferation, activation and cytotoxicity (134)

Arpaia N, Campbell C, Fan X, Dikiy S, Van Der Veeken J, Deroos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Since there are counterfeit versions out there and compounded versions will no longer be available, should I reconsider starting on drugs like Ozempic, Mounjaro, Wegovy and Zepbound

Men who default to whatever sounds palatable, which is often carb-heavy comfort foods in smaller portions, miss the muscle preservation window

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